Hyaluronic acid is a popular ingredient used in skincare regimens today that can be found in products ranging from serums to sheet masks. It is a non-sulfated glycosaminoglycan molecule that occurs naturally in the skin in the extracellular matrix molecules. Hyaluronic acid is an important component in skin moisture because of its ability to retain water molecules therefore acting as a humectant. Skin aging is affected by both intrinsic and extrinsic processes. Intrinsic processes are unpreventable and include hormonal changes as you age such as decreased estrogens and androgens leading to less collagen. Extrinsic processes include ultraviolet radiation exposure which causes skin damage. As you age, hyaluronic acid polymers shrink and the epidermis loses hyaluronic acid which leads to dehydration, atrophy, and loss of elasticity of the skin. There was a double blind, randomized study done to evaluate the effectiveness of a hyaluronic acid based product to decrease aging signs and improve face volume in wrinkles. The tested product was called Fillerina and the study was done with 40 female subjects with 20 divided into the 2 groups. The subjects’ loss of volume of their face contours, cheekbones and lips as well as wrinkles depth and volume were measured before the start of the study and after day 7, 14, and 30. Compared to the placebo group, the treatment group had an improvement in skin sagging and decreased wrinkle depth and volume. The placebo group had a slight worsening of their skin sagging but this can be due to normal differences in how much a person's skin sags. Overall, it was shown that the use of hyaluronic acid can improve skin moisturization and the appearance of aged skin.
Nobile V, Buonocore D, Michelotti A, Marzatico F. Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial of efficacy and safety. J Cosmet Dermatol. 2014;13(4):277-287. doi:10.1111/jocd.12120
Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-258. doi:10.4161/derm.21923